This book describes the behavioral ecology of American bison. There is also a substantial section on the ecology of the central grasslands including the behavioral ecology of a number of its vertebrates, especially, but not only, those that interact with the bison. This includes predators -- wolves, grizzly bear, badgers, black-footed ferrets and coyotes -- but also other herbivores -- e.g prairie dogs and pronghorn. There is also a description of the ecology of some of the diseases and parasites that afflict bison -- anthrax, brucellosis, deer ticks. The book also describes the current understanding of the impact of humans on bison, especially their destruction of the population and conservation. Unlike most books on bison this book does not address the religious and cultural significance of bison for Native Americans, though it does touch on the bison's economic significance. My book discusses humans primarily in terms of their impact on the bison. My book is too narrow be a suitable text for a course in animal behavior, but could be useful as a text or supplementary text in an introductory or survey course on wildlife ecology, conservation biology or an upper division course in animal behavior.